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Strain Sensitivity of Albino Rats to Reserpine

Abstract

DURING work on the effects of reserpine on chromaffin tissue, it became apparent that albino rats of Sprague–Dawley and Wistar strains differed markedly in their sensitivity to reserpine. This phenomenon has been investigated by observing the loss of catechol amines by the adrenal medulla in response to intravenous injections of 1, 5, 10 and 15 mgm./kgm. of the drug.

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COUPLAND, R. Strain Sensitivity of Albino Rats to Reserpine. Nature 181, 930–931 (1958). https://doi.org/10.1038/181930a0

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  • DOI: https://doi.org/10.1038/181930a0

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