Abstract
THE use of hydralazine (1-hydrazinophthalazine) for the control of human hypertension was followed by the recognition of serious and undesirable side-effects. The similarity of some of these effects to disseminated lupus erythematosus led to the investigation of the influence on the normal dog of toxic doses of this drug1,2. These experiments failed to provide satisfactory evidence for the production in the dog of an experimental model of disseminated lupus erythematosus.
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References
Comens, P., J. Lab. Clin. Med., 47, 444 (1956).
Gardner, D. L., Brit. J. Exp. Path., 38, 227 (1957).
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GARDNER, D. Lesions in the Hypertensive Rat Kidney produced by Hydralazine. Nature 181, 915 (1958). https://doi.org/10.1038/181915a0
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DOI: https://doi.org/10.1038/181915a0
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