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Direct Determination of the Active Phase of End-Plate Potential


IT is well known that the duration of transmitter action in neuromuscular transmission is very brief, of the order of 4 msec., and prolonged decline of the end-plate potential is due to the slow dissipation of charge along and across the resting membrane1–4. The time course of the active phase of the neuro-musoular transmission has been calculated by some authors1,3, but it has not yet been obtained experimentally. In the present investigation the time course of the active phase of the transmitter producing the end-plate potential was recorded by a refined voltage clamp method (the original method was described by Hodgkin et al. 5).

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  1. 1

    Eccles, J. C., Katz, B., and Kuffler, S. W., J. Neurophysiol., 4, 362 (1941).

  2. 2

    Kuffler, S. W., J. Neurophysiol., 5, 309 (1942).

  3. 3

    Katz, B., Proc. Roy. Soc., B, 135, 506 (1948).

  4. 4

    Fatt, P., and Katz, B., J. Physiol., 115, 320 (1951).

  5. 5

    Hodgkin, A. L., Huxley, A. F., and Katz, B., J. Physiol., 116, 424 (1952).

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