Letter | Published:

A Possible Basis for the Anti-inflammatory Activity of Salicylates and other Non-Hormonal Anti-Rheumatic Drugs


RECENT studies have shown that sodium salicylate and acetyl-salicylic acid increase oxygen consumption in rats, rabbits and man1–3. Sproull has shown that both sodium salicylate and 2 : 4-dinitrophenol stimulate metabolism in mouse-liver slices4, but has recently found a difference between the slopes of the concentration–response curves for the two compounds5. Reid has also directed attention to these similarities, and has shown that both compounds inhibit the growth of wheat coleoptiles6. Cochran3 suggested that the stimulation of respiration by salicylate may be of fundamental importance in the therapeutic action of the drug.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Meade, B. W., Ann. Rheum. Dis., 13, 60 (1954).

  2. 2

    Reid, J., Scot. Med. J., 2, 91 (1957).

  3. 3

    Cochran, J. B., Brit. Med. J., ii, 964 (1952); i, 733 (1954).

  4. 4

    Sproull, D. H., Brit. J. Pharmacol., 9, 262 (1954).

  5. 5

    Sproull, D. H., Biochem. J., 66, 527 (1957).

  6. 6

    Reid, J., Nature, 179, 484 (1957).

  7. 7

    Loomis, W. F., and Lipmann, F., J. Biol. Chem., 173, 807 (1948).

  8. 8

    Brody, T. M., J. Pharmacol., 117, 39 (1956).

  9. 9

    Penniall, R., Kalnitsky, G., and Routh, J. I., Arch. Biochem. Biophys., 64, 390 (1956).

  10. 10

    Smith, M. J. H., and Jeffrey, S. W., Nature, 178, 310 (1956).

  11. 11

    Wilhelmi, G., Schweiz. med. Wschr., 79, 577 (1949).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.