Letter | Published:

Degradation of Steroidal Sapogenins to 16-Dehydropregnan-20-ones


THE need for improving the reactions whereby steroidal sapogenins, now in abundant supply, are transformed into pregnane derivatives has recently been re-emphasized1. Earlier publications have dealt definitively with the entire sequence, so that the original Marker procedure has now been improved at each stage2.

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  1. 1

    Chakravarti, D., Chakravarti, R. N., and Mitra, M. N., Nature, 179, 1188 (1957).

  2. 2

    Wall, M. E., Kenney, H. E., and Rothman, E. S., J. Amer. Chem. Soc., 77, 5665 (1955). Cameron, A. F. B., Evans, R. M., Hamlet, J. C., Hunt, J. S., Jones, P. G., and Long, A. G., J. Chem. Soc., 2807 (1955).

  3. 3

    Sato, Y., Katz, A., and Mosettig, E., J. Amer. Chem. Soc., 74, 538 (1952).

  4. 4

    Lapin, H., and Sannie, C., Bull. Soc. Chim., 1552 (1955).

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