Abstract
Two of the main problems concerning the histogenesis of giant cell tumours of bones have been: (1) the nature and function of the giant cell—this has been variously classified as an endothelial cell, a foreign body giant cell, a megakaryocyte, an osteoclast or as a giant cell formed by agglomeration or fusion of stromal cells; (2) the histogenesis of the giant cell—the overwhelming consensus of opinion among the supporters and opposers of the osteoclast nature of the giant cell1–5 suggests that the giant cells are formed from the spindle-shaped stromal cells.
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PEPLER, W. Histogenesis of Osteoclastomata. Nature 181, 633 (1958). https://doi.org/10.1038/181633a0
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DOI: https://doi.org/10.1038/181633a0
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