Abstract
IT has been reported1,2 that as late as two months after denervation of the gastrocnemius muscle the end-plates still reacted positively to a histochemical test for cholinesterase. The test was made by the thiocholine method of Koelle and Friedenwald3. Recent development of the diver technique for quantitative determination of cholinesterase activity in individual cells4,5 has made it possible to record quantitatively the observed histochemical reaction of the end-plates after denervation.
Similar content being viewed by others
Article PDF
References
Gerebtzoff, M. A., and Vandermissen, L., Ann. d'Histochim., 1, 221 (1956).
Bergner, A. D., Brit. J. Exp. Path., 48, 160 (1957).
Koelle, G. B., and Friedenwald, J. S., Proc. Soc. Exp. Biol. and Med., 70, 617 (1949).
Zajicek, J., and Zeuthen, E., Exp. Cell Res., 11, 568 (1956).
Zajicek, J., Acta Physiol. Scand., 40, Supp. 158 (1957).
Koelle, G. B., J. Pharmacol., 103, 153 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BRZIN, M., ZAJICEK, J. Quantitative Determination of Cholinesterase Activity in Individual End-plates of Normal and Denervated Gastrocnemius Muscle. Nature 181, 626 (1958). https://doi.org/10.1038/181626a0
Issue Date:
DOI: https://doi.org/10.1038/181626a0
This article is cited by
-
Molecular forms and localization of acetylcholinesterase and nonspecific cholinesterase in regenerating skeletal muscles
Neurochemical Research (1987)
-
Attachment of acetylcholinesterase to structures of the motor endplate
Histochemistry (1979)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.