Abstract
INVESTIGATIONS on the release of histamine slow-reacting substance from the perfused anaphylactic lung of the guinea pig reveal that cortisone is not inhibitory to the release of either substance. On the other hand, in as low a concentration as 1 in 140,000 the response of the guinea pig gut to histamine and slow-reacting substance is greatly reduced if the cortisone is left in contact with the gut for 1–3 min. Contact for 10 sec. is without significant effect so that assay of the output of histamine and slow-reacting substance is satisfactory on the isolated gut of the guinea pig. This effect, owing to the delay, may be due to intracellular action of cortisone on the effector organ.
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TRETHEWIE, E. Anti-allergic Effect of Cortisone. Nature 181, 625 (1958). https://doi.org/10.1038/181625a0
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DOI: https://doi.org/10.1038/181625a0
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