Demonstration of Antibody in Passive Transplantation Immunity to Crocker Tumour in Mice, using the Schultz-Dale Technique

Abstract

MITCHISON¹ reported a simple and effective procedure for passively transferring transplantation immunity to a mouse lympho-sarcoma by injecting minced, regional lymph nodes intraperitoneally and draining the grafted areas of actively immunized mice. This phenomenon was later confirmed by Billingham et al. ² using skin homografts. They preferred to call it ‘adoptively acquired immunity’. Using the same technique¹, a similar transfer of passive immunity to homologous or heterologous tumour transplantation was conferred upon rats^3,4. The criteria of immunization adopted in these experiments was the ability of the animal to cause regression of a viable implant of the tumour, or to hasten the breakdown of the skin homografts.