Mode of Action of Chelates in protecting against Clostridium perfringens Toxin

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Abstract

IT was reported previously that ethylenediamine tetraacetic acid was capable of protecting mice against the toxin of Clostridium perfringens 1. The protection thus afforded was shown to be probably due to the removal of a metallic ion or ions necessary for the activity of the toxin from the area where the toxin was acting. Inasmuch as the metallic ion or ions necessary for the action of the toxin apparently were higher in the preferential chelation series than calcium, the calcium chelate was shown to be able to protect when given systemically2. In this report, studies on the duration of the protection afforded by calcium ethylenediamine tetraacetic acid are presented and their implications are discussed.

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References

  1. 1

    Moskowitz, M., et al., Science, 123, 1077 (1956).

  2. 2

    Moskowitz, M., Proc. Soc. Exp. Biol. Med., 92, 706 (1956).

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MOSKOWITZ, M. Mode of Action of Chelates in protecting against Clostridium perfringens Toxin. Nature 181, 550–551 (1958) doi:10.1038/181550a0

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