Phosphorylase Activity of Primary Rat Liver Cancer

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THE level of glycogen in the majority of tumours is considerably lower than in the normal homologous tissues1. According to Dickens and Weil-Malherbe2 the glycogen content of primary rat hepatoma is lower than that of normal rat liver. As found recently by Garanson et al. 3, the phosphorylase activity of a transplantable rat hepatoma is very low. According to these authors, the addition of adenosine 5-phosphate greatly increases the phosphorylase activity of hepatoma tissue, up to the values found with normal rat liver. Hence the low content of glycogen in hepatoma might be due to a lack of adenosine 5-phosphate, rather than a deficiency in the amount of the phosphorylase itself. On the other hand, Le Page5 found that rat hepatoma contains approximately twice as much adenosine 5-phosphate as normal rat liver. We have therefore studied the phosphorylase activity of primary rat liver carcinoma and the activating effect of adenosine 5-phosphate on it.

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  1. 1

    Butenand, A., and Dannenberg, H., “Die Biochemie der Geschwülste in Handbuch der allgemeine Pathologie”, 6, Part 3, 107 (Springer, 1956).

  2. 2

    Dickens, F., and Weil-Malherbe, H., Cancer Res., 3, 73 (1943).

  3. 3

    Goranson, E., McBride, J., and Weber, G., Cancer Res., 14, 227 (1954).

  4. 4

    Hadjiolov, A. A., Bull. Inst. Morphol. Acad. Sci. Bulgarie, 2, 423 (1957).

  5. 5

    Le Page, G. A., Cancer Res., 8, 193 (1948).

  6. 6

    Potter, V. R., in Colowick, S., and Kaplan, N., “Methods in Enzymology”, 1, 10 (Acad. Press, New York, 1955).

  7. 7

    Sutherland, E. W., in Colowick, S., and Kaplan, N.>, “Methods in Enzymology”, 1, 213 (Acad. Press, New York, 1955).

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HADJIOLOV, A., DANCHEVA, K. Phosphorylase Activity of Primary Rat Liver Cancer. Nature 181, 547–548 (1958) doi:10.1038/181547a0

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