Letter | Published:

A New ‘Deleted’ Rh-Chromosome


IN 1950, Race, Sanger and Selwyn reported1 a very unusual Rh phenotype characterized by an extraordinary strong reaction with anti-D sera and completely negative reaction with anti-C, anti-c, anti-E and anti-e sera. The case was explained as the homozygous form of a partially deleted Rh chromosome, designated D − −. Since then several examples of this chromosome have been reported, and further other partial deletions have been found2.

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  1. 1

    Race, R. R., Sanger, R., and Selwyn, J. G., Nature, 166, 520 (1950).

  2. 2

    Wiener, A. S., Gordon, E. B., and Cohen, L., Amer. J. Hum. Genet., 4, 363 (1952). Waller, R. K., Sanger, R., and Bobbitt, O. B., Brit. Med. J., i, 198 (1953). Levine, P., Koch, E. A., McGee, R. T., and Hill, G. H., Amer. J. Clin. Path., 24, 292 (1954). Gunson, H. H., and Donohue, W. L., Vox Sang. (in the press). Henningsen, K., Vox Sang. (in the press).

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