Isomeric Chondroitin Sulphates

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A RECENT communication1 claims to “confirm Meyer's hypothesis that chondroitin sulphates A and C are only two fractions of the same polydisperse substance”. Apparent lack of agreement in nomenclature2–4 further emphasizes the need for clear differentiation of the isomeric chondroitin sulphates of connective tissue. These three substances, chondroitin sulphate A, chondroitin sulphate B and chondroitin sulphate C, respectively, in the nomenclature of Meyer et al. 2, have been found to be linear polyelectrolytes with similar chain configuration-charge relationships. Chondroitin sulphates A and C have been clearly distinguished as molecular individuals by comparison of molecular constants and physical properties.

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MATHEWS, M. Isomeric Chondroitin Sulphates. Nature 181, 421–422 (1958) doi:10.1038/181421a0

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