Insulin - Cortisone Relationship in Experimental Teratogenesis

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Abstract

IT is well known that the administration of large amounts of cortisone to experimental animals is associated with the production of hyperglycæmia1. There is also evidence from clinical cases that in diabetes the therapeutic use of cortisone increases considerably the daily amount of insulin required to maintain the blood-sugar within normal limits2. The nature of this contra-insulin effect of cortisone is uncertain, but it has been suggested that it may be due to excessive destruction of insulin since there is no definite evidence that contra-insulin factors are responsible for a marked increase in the peripheral requirements for insulin3.

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References

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    Ingle, D. J., Endocrinol., 29, 649 (1941).

  2. 2

    Boland, E. W., and Headley, N. E., J. Amer. Med. Assoc., 141, 301 (1949).

  3. 3

    Mirsky, I. A., Recent Prog. Hormone Res., 13, 429 (1957).

  4. 4

    Millen, J. W., and Woollam, D. H. M., Brit. Med. J., ii, 196 (1957).

  5. 5

    Woollam, D. H. M., and Millen, J. W., Brit. Med. J., ii, 197 (1957).

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MILLEN, J., WOOLLAM, D. Insulin - Cortisone Relationship in Experimental Teratogenesis. Nature 181, 418 (1958) doi:10.1038/181418a0

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