Effects of Orotic Acid on Coenzyme A and Pantothenic Acid of Liver in Vitamin B12 Deficiency

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OROTIC ACID was found to reduce the vitamin B12 requirement for growth and for the betaine–homocysteine transmethylase activity of liver in rats fed corn/soybean meal ration deficient in vitamin B12 1. These results suggested a metabolic relationship between orotic acid and vitamin B12. To ascertain whether this metabolic relationship was limited or more extended, we have directed our research towards other biochemical modifications reported in vitamin B12 deficiency.

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MORUZZI, G., VIVIANI, R., MARCHETTI, M. et al. Effects of Orotic Acid on Coenzyme A and Pantothenic Acid of Liver in Vitamin B12 Deficiency. Nature 181, 416–417 (1958) doi:10.1038/181416a0

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