Mode of Action of Organophosphorus Insecticides

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IT is widely held that organic phosphates exert their insecticidal action by the inhibition of cholinesterase activity in the nervous system. Definite proof of this theory, however, has never been furnished and some years ago doubt as to its correctness was expressed by Hopf1 and also by Lord and Potter2.

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  1. 1

    Hopf, H. S., Ann. App. Biol., 39, 193 (1952); 41, 248 (1954).

  2. 2

    Lord, K. A., and Potter, C., J. Sci. Food Agric., 10, 490 (1954).

  3. 3

    Aldridge, W. N., and Davison, A. N., Biochem. J., 55, 763 (1953).

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VAN ASPEREN, K. Mode of Action of Organophosphorus Insecticides. Nature 181, 355–356 (1958) doi:10.1038/181355a0

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