Effect of Thiosemicarbazones on the Multiplication of Tobacco Mosaic Virus

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WHILE much effort has been expended on the chemotherapy of plant virus diseases1, it seems to provide no conclusive evidence. Iwasaki et al. 2 obtained marked inhibition of influenza and Newcastle virus by thiosemicarbazones and related compounds. We have performed tests to determine the effect of certain of the thiosemicarbazone derivatives on the multiplication of tobacco mosaic virus in detached tobacco leaf tissues.

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  1. 1

    Schneider, I. R., Phytopath., 44, 243 (1954). Schlegel, D. E., and Rawlins, T. E., J. Bacteriol., 67, 103 (1954). Tamm, Igor, Yale J. Biol. Med., 29, 33 (1956). Porter, F. M., et. al., Phytopath., 47, 179 (1957).

  2. 2

    Iwasaki, K., et al., Kitasato Arch. Exp. Med., 28, 31 (1955).

  3. 3

    Hirai, T., Shimomura, T., and Nishikawa, Y., Ann. Phytopath. Soc. Japan, 22, 70 (1957).

  4. 4

    Bancroft, J. B., and Curtis, R. W., Phytopath., 47, 79 (1957).

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HIRAI, T., SHIMOMURA, T. & NISHIKAWA, Y. Effect of Thiosemicarbazones on the Multiplication of Tobacco Mosaic Virus. Nature 181, 352–353 (1958) doi:10.1038/181352a0

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