Immediate Effect of 1-3 :5 : 3′-Tri-iodothyroacetic Acid on Metabolic Rate and Body Temperature in Hypophysectomized Rats and the Action of Cortisone

Article metrics

Abstract

THE acetic acid analogues of thyroxine and tri-iodothyronine have been found to raise the metabolic rate of the thyroidectomized1–4 and the hypophysectomized3,4 rat without latency. In hypo-physectomized rats intravenous injection of a few micrograms of tri-iodothyroacetic acid is invariably followed by a marked rise in oxygen consumption and body temperature, while only about half the thyroidectomized and none of the intact rats show a similar response4.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Thibault, O., and Pitt-Rivers, R., Lancet, 268, 285 (1955). Thibault, O., Arch. Sci. Physiol., 10, 423 (1956).

  2. 2

    Donhoffer, Sz., Acta Physiol. Hung., 10, 131 (1956).

  3. 3

    Varga-Nagy, I., and Lajos, T., Comm. 22nd Ann. Meet. Hung. Physiol. Soc., 50 (1955).

  4. 4

    Várnai, I., Comm. 23rd Ann. Meet. Hung. Physiol Soc., 56 (1957).

  5. 5

    Westphal, O., Lüderitz, O., Eichenberger, E., and Keiderling, W., Z. Naturforsch., 7, B, 536 (1952). Lüderitz, O., and Westphal, O., ibid., 7, B, 548 (1952).

  6. 6

    Noble, R. L., in Pincus-Thiman, “The Hormones”, 3, 780 (Academic Press, New York, 1955).

  7. 7

    Mestyán, Gy., Szegvári, Gy., and Donhoffer, Sz., Kisérletes Orvos tudomány, 9, 436 (1957).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

DONHOFFER, S., VÁRNAI, I. & SZIEBERT-HORVÁTH, E. Immediate Effect of 1-3 :5 : 3′-Tri-iodothyroacetic Acid on Metabolic Rate and Body Temperature in Hypophysectomized Rats and the Action of Cortisone. Nature 181, 345–346 (1958) doi:10.1038/181345a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.