Immediate Effect of 1-3 :5 : 3′-Tri-iodothyroacetic Acid on Metabolic Rate and Body Temperature in Hypophysectomized Rats and the Action of Cortisone

Nature volume 181, pages345–346(1958)Cite this article

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Abstract

THE acetic acid analogues of thyroxine and tri-iodothyronine have been found to raise the metabolic rate of the thyroidectomized1–4 and the hypophysectomized3,4 rat without latency. In hypo-physectomized rats intravenous injection of a few micrograms of tri-iodothyroacetic acid is invariably followed by a marked rise in oxygen consumption and body temperature, while only about half the thyroidectomized and none of the intact rats show a similar response4.

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References

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    Mestyán, Gy., Szegvári, Gy., and Donhoffer, Sz., Kisérletes Orvos tudomány, 9, 436 (1957).

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  1. Institute of Pathophysiology, University Medical School, Pécs, Hungary

    • SZ. DONHOFFER
    • , I. VÁRNAI
    •  & E. SZIEBERT-HORVÁTH

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DONHOFFER, S., VÁRNAI, I. & SZIEBERT-HORVÁTH, E. Immediate Effect of 1-3 :5 : 3′-Tri-iodothyroacetic Acid on Metabolic Rate and Body Temperature in Hypophysectomized Rats and the Action of Cortisone. Nature 181, 345–346 (1958) doi:10.1038/181345a0

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