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Immediate Effect of 1-3 :5 : 3′-Tri-iodothyroacetic Acid on Metabolic Rate and Body Temperature in Hypophysectomized Rats and the Action of Cortisone

Abstract

THE acetic acid analogues of thyroxine and tri-iodothyronine have been found to raise the metabolic rate of the thyroidectomized1–4 and the hypophysectomized3,4 rat without latency. In hypo-physectomized rats intravenous injection of a few micrograms of tri-iodothyroacetic acid is invariably followed by a marked rise in oxygen consumption and body temperature, while only about half the thyroidectomized and none of the intact rats show a similar response4.

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References

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DONHOFFER, S., VÁRNAI, I. & SZIEBERT-HORVÁTH, E. Immediate Effect of 1-3 :5 : 3′-Tri-iodothyroacetic Acid on Metabolic Rate and Body Temperature in Hypophysectomized Rats and the Action of Cortisone. Nature 181, 345–346 (1958). https://doi.org/10.1038/181345a0

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