A Histoautoradiographic Study of the Effect of Section of the Facial Nerve on the Uptake of Methionine-35S by the Cells of the Facial Nerve Nucleus

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Abstract

RETROGRADE degeneration of nerve cells was first described by Nissl in 18921. Its main features are swelling of the cells, breaking up of the cytoplasmic chromophile granules and displacement of the nucleus to the cell margin. These changes occur after a lesion in the axon, after excitation of long duration or after certain virus diseases, as, for example, poliomyelitis. It is still not known whether these changes are entirely degenerative in nature or are due to increased metabolic activity associated with increased synthesis of protein molecules. The biochemical processes underlying these changes have so far not been adequately explained. The results obtained from ultra-violet microspectrography of the nucleic acid content of these cells have not been entirely satisfactory2.

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References

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    Nissl, F., Allg. Z. f. Physiol., 48, 197 (1892).

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    Hydén, H., “Neurochemistry”, 204 (Ch. C. Thomas, Springfield, Illinois, 1955).

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    Fischer, J., Koloušek, J., and Lodin, Z., Nature, 178, 1122 (1956).

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    Cohn, P., Gaitonde, M. K., and Richter, D., J. Physiol., 126, 7P (1954).

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    Koloušek, J., Fischer, J., and Lodin, Z., Cs. Morfologie, 4, 302 (1956); Acta Histochemica, 3, 328 (1956).

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    Bélanger, L. F., Anat. Rec., 107, 149 (1950).

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FISCHER, J., LODIN, Z. & KOLOUŠEK, J. A Histoautoradiographic Study of the Effect of Section of the Facial Nerve on the Uptake of Methionine-35S by the Cells of the Facial Nerve Nucleus. Nature 181, 341–342 (1958) doi:10.1038/181341a0

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