Synthesis of Succinate from Acetate by an Enzyme System of Pig Heart Muscle

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Abstract

THE oxidation and condensation of two molecules of acetate to form succinate was first proposed by Thunberg1. Many later attempts have been made to demonstrate this reaction, with for the most part equivocal results. Recently, evidence has been presented2 that the reaction does not occur in E. coli. On the other hand, evidence has been presented3,4 that extracts of Tetrahymena catalyse the Thunberg reaction at a slow rate, and Seaman5 has presented evidence that mammalian tissue catalyses the reduction of succinate to acetyl coenzyme A.

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References

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    Thunberg, T., Skand. Arch. Physiol., 40, 1 (1920).

  2. 2

    Swim, H. E., and Krampitz, L. O., J. Bact., 67, 426 (1954).

  3. 3

    Barron, E. S. G., and Ghiretti, F., Biochim. Biophys. Acta, 12, 239 (1953).

  4. 4

    Seaman, G. R., and Naschke, M. D., J. Biol. Chem., 217, 1 (1955).

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    Seaman, G. R., J. Biol. Chem., 228, 149 (1957).

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    Kornberg, H. L., and Beevers, H., Nature, 180, 35 (1957).

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    Wong, D. T. O., and Ajl, S. J., J. Amer. Chem. Soc., 78, 3230 (1956).

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    Madsen, N. B., Biochim. Biophys. Acta (in the press).

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DAVIES, D. Synthesis of Succinate from Acetate by an Enzyme System of Pig Heart Muscle. Nature 181, 339–340 (1958) doi:10.1038/181339a0

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