Abstract
WE have recently reported1 the preparation and acute toxicity of a number of salts of basic antibiotics with acid vitamins. However, the good results obtained with the pantothenates in the reduction of the neurotoxicity of streptomycin2,3 have not been as marked in the prevention of nephrotoxicity and other side effects produced by neomycin4 and viomycin4,5. This prompted us to prepare other types of salts of antibiotics.
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References
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ALVES, F., GRAÇA, M. & BAPTISTA, H. A New Class of Antibiotic Salts of Reduced Toxicity. Nature 181, 182–183 (1958). https://doi.org/10.1038/181182a0
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DOI: https://doi.org/10.1038/181182a0
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