Abstract
Leder and Handler1 have described the synthesis of pyridine nucleotide from nicotinamide and glucose by human erythrocyte homolysates in amounts as much as ten times the normal content and they identified the synthesized material as nicotinamide mononucleotide. These authors also suggested that fructose diphosphate and adenosine triphosphate were required for optimal synthesis of nicotinamide mononucleotide. While synthesis of pyridine nucleotide is thus known to occur in vitro by washed human erythrocytes, its presence and its synthesis in other mammalian species have not yet been examined.
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References
Leder, I. G., and Handler, P., “Symposium on Phosphorus Metabolism”, 1, 421 (Johns Hopkins Press, 1951).
Leder, I. G., and Handler, P., J. Biol. Chem., 189, 889 (1951).
Levitas, N., Robinson, J., Rosen, F., and Perlzweig, W. A., J. Biol. Chem., 167, 169 (1947).
Rowen, J. W., and Kornberg, A., J. Biol. Chem., 193, 497 (1951).
Preiss, J., and Handler, P., J. Biol. Chem., 225, 759 (1957).
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TULPULE, P. Species Difference in Pyridine Nucleotide Synthesis by Erythrocytes. Nature 181, 1804–1805 (1958). https://doi.org/10.1038/1811804b0
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DOI: https://doi.org/10.1038/1811804b0
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