Abstract
ANTISERA prepared by injecting rabbits with cytoplasmic fractions or homogenates of human tissues frequently contain antibodies directed against substances extractable from the tissue with organic solvents and presumably lipid in nature. Material derived from tumours is reported to be more effective than that from normal tissues in eliciting this type of antibody1, suggesting that tumours may contain larger quantities of one or several lipoprotein antigens or possibly antigens qualitatively different. Exploration of this problem by the methods of immunochemical analysis is obstructed by several complications: the antigenic complexity of lipid extracts, the multiplicity of antibodies in the antiserum reagents, and the paucity of information regarding non-specific lipid–protein interactions for many classes of lipids. A fourth complication is of even greater moment than the other three combined, namely, the fact that specific lipid–protein interactions are markedly influenced by certain ubiquitous, non-specific lipids2.
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RAPPORT, M., GRAF, L., SKIPSKI, V. et al. Cytolipin H, a Pure Lipid Hapten isolated from Human Carcinoma. Nature 181, 1803–1804 (1958). https://doi.org/10.1038/1811803a0
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DOI: https://doi.org/10.1038/1811803a0
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