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Bactericidal Activity of Macrophages in vitro against Escherichia coli

Nature volume 181, pages 1738–1739 (1958)Cite this article

Abstract

IN spite of the strong evidence for an important role of macrophages in vivo, in protecting the animal host against infections, there has been no conclusive demonstration of bactericidal activity by macrophages in vitro. Several workers in recent years have studied the interactions between tubercle bacilli and macrophages from rabbits or guinea pigs surviving in tissue culture1. Interpretation of their results is made less certain by the presence of antibiotics in the medium, but all agree in finding little or no bactericidal activity by macrophages against tubercle bacilli under their conditions.

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References

  1. Suter, E., J. Exp. Med., 97, 235 (1958). Mackaness, G. B., Amer. Rev. Tuberc., 69, 495 (1954).

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  1. Wright-Fleming Institute of Microbiology, St. Mary's Hospital, London, W.2

    D. ROWLEY

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  1. D. ROWLEY
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ROWLEY, D. Bactericidal Activity of Macrophages in vitro against Escherichia coli . Nature 181, 1738–1739 (1958). https://doi.org/10.1038/1811738b0

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