Abstract
SINCE the introduction of radioactive labels in biological research a tendency has arisen to measure the specific radioactivity of nucleic acid components (usually expressed as counts per minute per µmole or mgm. material) and to equate such measurements with a synthesis of deoxyribonucleic acid, or even growth-rate of tissues. Certain factors are, however, frequently neglected.
Similar content being viewed by others
Article PDF
References
Howard, A., and Pelc, S. R., Heredity, Supp. 6, 261 (1953).
Lajtha, L. G., Oliver, R., and Ellis, F., Brit. J. Cancer, 8, 367 (1954).
Lajtha, L. G., Oliver, R., Kumatori, T., and Ellis, F., Radiation Res., 8, 1 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LAJTHA, L. Pitfalls of Specific Radioactivity in measuring Synthesis of Deoxyribonucleic Acid. Nature 181, 1609 (1958). https://doi.org/10.1038/1811609a0
Issue Date:
DOI: https://doi.org/10.1038/1811609a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.