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Antibody Production by Single Cells

Nature volume 181, pages 1419–1420 (1958)Cite this article

Abstract

FAGREUS1 and others2,3 have shown that certain tissues from pre-sensitized animals can form antibody in vitro. This communication describes a technique whereby antibody production by single cells isolated in microdroplets can be detected. The technique is based on specific immobilization of Salmonella serotypes by anti-flagellar antibody. It was observed that single cells from a rat, simultaneously stimulated with two antigens, formed detectable amounts of one or the other antibody.

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Author notes

  1. JOSHUA LEDERBERG: Fulbright Visiting Professor of Bacteriology, University of Melbourne; from Department of Medical Genetics, University of Wisconsin, Madison.

Authors and Affiliations

  1. Walter and Eliza Hall Institute of Medical Research, Melbourne

    G. J. V. NOSSAL & JOSHUA LEDERBERG

Authors
  1. G. J. V. NOSSAL
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  2. JOSHUA LEDERBERG
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NOSSAL, G., LEDERBERG, J. Antibody Production by Single Cells. Nature 181, 1419–1420 (1958). https://doi.org/10.1038/1811419a0

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