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Alterations in the Ultrastructure of the Blood–Air Barrier in the Mouse Lung after Inhalation of Colloidal Gold Particles


MANY problems concerning the morphology of lung-tissue, revealed by optical microscopy, have been solved with the electron microscope1–3. But the origin of the alveolar lining has not been elucidated so far. To throw some light on this question we have studied, by means of the electron microscope, the changes in the capillaries and lung alveoles of mice after inhalation of colloidal gold aerosols. We wished, first, to trace the heavy particles of gold in the phagocyting cells; secondly, to stimulate all cells activated by powerful irritation.

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  1. 1

    Low, F. N., Anat. Rec., 117, 241 (1953).

  2. 2

    Bargmann, W., and Knoop, A., Z. Zellforsch., 44, 263 (1956).

  3. 3

    Policard, A., Collet, A., and Giltaire-Raylte, I., C.R. Acad. Sci., Paris, 240, 2363 (1955).

  4. 4

    Policard, A., Collet, A., and Noufflard, H., La Sem. Hop. Path. Biol., 33, 5, 1471 (1957).

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