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Effect of Stress and Cortisone on the Cytomorphology of Pituitary Grafts in Rats


IN the course of previous investigations1–3 it was demonstrated that following stress (administration of formalin, intensive dehydration) the number of basophil cells in the adenohypophysis of rats increased considerably. For the development of this phenomenon the presence of the adrenal gland is needed: thus if formalin stress is applied in adrenalectomized animals, basophil hyperplasia fails to develop. The importance of the adrenal cortex is also supported by the fact that cortisone treatment also increases the number of the basophils4.

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    Bachrach, D., Kovács, K., Dávid, M., Horváth, É., and Korpássy, B., Acta Morphol., Hung., 4, 429 (1954).

  2. 2

    Kovács, K., Jakobovits, A., Dávid, M., Horváth, É., Bachrach, D., and Korpássy, B., Endokrinologie, 32, 281 (1955).

  3. 3

    Kovács, K., Dávid, M., and Korpássy, B., Lancet, i, 638 (1957).

  4. 4

    Kovács, K., Dávid, M. A., and Korpássy, B., Endokrinologie (in the press).

  5. 5

    Harris, G. W., “Neural Control of the Pituitary Gland” (Edward Arnold, Ltd., London, 1955).

  6. 6

    Greep, R. O., and Barrnett, R. J., Endocrinology, 49, 172 (1951).

  7. 7

    Goldberg, R. C., and Chaikoff, I. L., Anat. Rec., 112, 265 (1952).

  8. 8

    Siperstein, E. R., and Greer, M. A., J. Nat. Cancer Inst., 17, 569 (1956).

  9. 9

    Nikitovitch-Winer, M., and Everett, J. W., Nature, 180, 1434 (1957).

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