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Demonstration of Thyroglobulin in the Presence of Other Proteins by the Precipitin Reaction


RECENTLY Doniach and Roitt1 found that the sera of patients with Hashimoto's disease contained auto-antibodies to human thyroglobulin. They demonstrated this by diffusion-precipitation reactions in agar gels. Positive precipitin reactions were obtained by allowing the sera to react with saline extracts of human thyroid or purified thyroglobulin. We have investigated the possibility of using this precipitin reaction in an immuno-electrophoretic method for the demonstration of thyroglobulin in the presence of other proteins.

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