Letter | Published:

Demonstration of Thyroglobulin in the Presence of Other Proteins by the Precipitin Reaction

Abstract

RECENTLY Doniach and Roitt1 found that the sera of patients with Hashimoto's disease contained auto-antibodies to human thyroglobulin. They demonstrated this by diffusion-precipitation reactions in agar gels. Positive precipitin reactions were obtained by allowing the sera to react with saline extracts of human thyroid or purified thyroglobulin. We have investigated the possibility of using this precipitin reaction in an immuno-electrophoretic method for the demonstration of thyroglobulin in the presence of other proteins.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Doniach, D., and Roitt, I. M., J. Clin. Endocrinol. Metab., 17, 1293 (1957).

  2. 2

    Kohn, J., Nature, 180, 986 (1957).

  3. 3

    Henry, R. J., Golub, O. J., and Sobel, C., Clin. Chem., 3, 49 (1957).

  4. 4

    Robbins, J., Peterman, M. L., and Rall, J. E., J. Biol. Chem., 208, 377, 387 (1954).

  5. 5

    Robbins, J., and Rall, J. E., Proc. Soc. Exp. Biol. and Med., 81, 530 (1952).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.