Letter | Published:

Antibody Production by Lymphocytes after in vitro Contact with Bacterial Antigen and Transfer to New-born Rabbits


THERE is as yet no direct evidence of antibody formation in lymphocytes. Neither descriptions of cytological changes of lymphocytes in lymphatic tissues during antibody production1, nor the proof of release of γ-globulin from lymphoid cells2, nor the demonstration of antibodies in tissue cultures of pure lymphocytes immunized in vivo 3 could reveal whether lymphocytes are producers or only carriers of antibodies. An attempt was made, therefore, to obtain antibody production after contact of lymphocytes from rabbit lymph with antigen in vitro.

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  1. 1

    Harris, T. N., and Harris, S., J. Exp. Med., 90, 169 (1949).

  2. 2

    White, A., Dougherty, T. F., Ann. N.Y. Acad. Sci., 46, 859 (1946).

  3. 3

    Wessleén, T., Acta Dermato-Venereologica (Stockholm), 32, 265 (1952).

  4. 4

    Sterzl, J., Folia Biologica (Praha), 3, 1 (1957).

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