Abstract
SEROLOGICAL and enzymic inhibition tests with simple sugars and oligosaccharides of known structure have in recent years given valuable indications about the sugars which are most important for specificity in the complex mucopolysaccharide materials possessing blood-group activity1. Di-and tri-saccharides of known structure which are composed of the sugars present in the blood-group substances are required in order to extend these observations; the enzymic syntheses of two such disaccharides which have not previously been described, α-D-galactosyl-(1→6)-N-acetyl-D-glucosamine (1) and α-D-galactosyl-(1→6) - N -acetyl-D-gal-actosamine (2), are reported here.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Watkins, W. M., and Morgan, W. T. J., Nature, 169, 825 (1952). Morgan, W. T. J., and Watkins, W. M., Brit. J. Exp. Path., 34, 94 (1953). Kabat, E. A., and Leskowitz, S., J. Amer. Chem. Soc., 77, 5159 (1955). Watkins, W. M., and Morgan, W. T. J., Nature, 175, 676 (1955); 178, 1289 (1956). Côté, R., and Morgan, W. T. J., ibid., 178, 1171 (1956).
Zillikin, F., Smith, P. N., Rose, C. S., György, P., J. Biol. Chem., 208, 299 (1954). Alessandrini, A., Schmidt, E., Zilliken, F., and György, P., J. Biol. Chem., 220, 71 (1956).
Wallenfels, K., Ann. Chem., 579, 113 (1952). Kuhn, R., Baer, H. H., and Gauhe, A., Chem. Ber., 88, 1713 (1955).
Watkins, W. M., Biochem. J., 54, xxxiii (1953), and unpublished observations.
Kuhn, R., Baer, H. H., and Gauhe, A., Chem. Ber., 88, 1713 (1955).
Kuhn, R., Baer, H. H., and Gauhe, A., Chem. Ber., 87, 1553 (1954).
Zilliken, F., Smith, P. N., Tomarelli, R. M., and György, P., Arch. Biochem. Biophys., 54, 398 (1955).
Bacon, J. S. D., and Edelman, J., Biochem. J., 48, 114 (1951).
Partridge, S. M., and Westall, R. G., Biochem. J., 42, 238 (1948).
Jeanloz, R. W., and Trémège, M., Fed. Proc., 15, 282 (1954).
Kuhn, R., Gauhe, A., and Baer, H. H., Chem. Ber., 87, 1138 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WATKINS, W. Enzymic Synthesis of Nitrogen-containing Disaccharides by α-Galactosyl Transfer. Nature 181, 117–118 (1958). https://doi.org/10.1038/181117a0
Issue Date:
DOI: https://doi.org/10.1038/181117a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
