Letter | Published:

Effect of Chymotrypsin on Cæruloplasmin

Abstract

INTEREST has been shown in the blue, copper-containing, serum oxidase cæruloplasmin, in particular because of its absence from the blood of subjects with hepatolenticular degeneration1. The copper of cæruloplasmin is firmly bound, being non-dialysable at neutral pH2. As part of a study of the mode of linkage of copper to the apo-enzyme, the effect of chymotryptic digestion on cæruloplasmin was investigated.

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References

  1. 1

    Scheinberg, I. H., and Gitlin, D., Science, 116, 484 (1952).

  2. 2

    Holmberg, C. G., Laurell, C. B., Acta Chem. Scand., 2, 550 (1948).

  3. 3

    Kekwick, R. A., and MacKay, M. E., Medical Research Council Special Report No. 286 (1954).

  4. 4

    Kominz, D. R. (personal communication).

  5. 5

    Mahler, H. R., Hubscher, G., and Baum, H., J. Biol. Chem., 216, 625 (1955).

  6. 6

    Azari, P. R., and Feeney, R. E., Fed. Proc., 16, 147 (1957).

  7. 7

    Scheinberg, I. H., and Morell, A. G., J. Clin. Invest., 36, 1193 (1957).

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