Letter | Published:

The Pyridine Ring and the Problem of its Biosynthesis

Abstract

THE relationships of anthranilic acid and tryptophane to nicotinic acid are well established in a number of organisms1 and it has been suggested that in the higher plants the pyridine ring may be formed in a like manner2. It has been shown, however, that tryptophane-3-14C is not a precursor of damascenine in Nigella damascena L., nor did it give rise to radioactive trigonelline when fed to pea seedlings3. It is possible that in the two plants studied the enzyme system necessary for the initial oxidation of tryptophane to kynurenine is lacking and that the hydroxyanthranilic acid in one case (damascenine) and the pyridine ring in the other (trigonelline) are synthesized from different precursors and by a different pathway.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Mehler, A. H., in “A Symposium on Amino Acid Metabolism”, edit. by McElroy, W. D., and Glass, H. B. (The Johns Hopkins Press, Baltimore, 1955).

  2. 2

    Mortimer, P. I., Nature, 172, 74 (1953).

  3. 3

    Leete, E., Marion, L., and Spenser, I. D., Can. J. Chem., 33, 405 (1955).

  4. 4

    Bowden, K., Nature, 172, 768 (1953).

  5. 5

    Leete, E., Chem. and Indust., 1270 (1957).

  6. 6

    Aronoff, S., Plant Physiol., 31, 355 (1956).

  7. 7

    Schall, C., Z. Electrochem., 21, 70 (1915); 19, 832 (1913).

  8. 8

    Morgan, G. T., and Moss, J. E., J. Chem. Soc., 121, 2866 (1922).

  9. 9

    Leete, E., J. Amer. Chem. Soc., 78, 3520 (1956).

  10. 10

    Smith, H. H., and Smith, C. R., J. Agric. Res., 65, 347 (1942).

  11. 11

    Kuffner, F., Schlick, K., and Bühn, H., Monatsh., 87, 749 (1956).

  12. 12

    Dawson, R. F., Christman, D. R., Andersen, R. C., Solt, M., D'Adamo, A. F., and Weiss, U., J. Amer. Chem. Soc., 78, 2645 (1956).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.