Allelomorphism and the Chemical Differences of the Human Hæmoglobins A, S and C

Abstract

IN previous communications on this subject, one of us1,2 reported that normal human hæmoglobin (A) and sickle-cell hæmoglobin (S) differ in only one out of nearly 300 amino-acids in the half-molecule, and that this is the only demonstrable difference in primary chemical structure. We now wish to report on a similar investigation into the structure of another abnormal human hæmoglobin—that of hæmoglobin C disease.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Ingram, V. M., Nature, 178, 792 (1956).

    ADS  Article  CAS  Google Scholar 

  2. 2

    Ingram, V. M., Nature, 180, 326 (1957).

    ADS  Article  CAS  Google Scholar 

  3. 3

    Michl, H., Monatsh. Chem., 82, 489 (1951).

    Article  CAS  Google Scholar 

  4. 4

    Fraenkel-Conrat, H., Harris, J. I., and Levy, A. L., “Methods of Biochemical Analysis”, 2, 359 (1955).

    Google Scholar 

  5. 5

    Scheinberg, I. H., Harris, R. S., and Spitzer, J. L., Proc. U.S. Nat. Acad. Sci., 40, 777 (1954).

    ADS  Article  CAS  Google Scholar 

  6. 6

    Neel, J. V., Science, 110, 64 (1949).

    ADS  Article  CAS  Google Scholar 

  7. 7

    Benzer, S., in “The Chemical Basis of Heredity”, edit. McElroy, W. D., and Glass, B., 70 (Johns Hopkins Press, Baltimore, 1957).

    Google Scholar 

  8. 8

    Pontecorvo, G., Cold Spring Harbor, Symp. Quant Biol., 21, 171 (1956).

    Article  CAS  Google Scholar 

  9. 9

    Neel, J. V., Ann. Human Genet., 21, 1 (1956).

    Article  CAS  Google Scholar 

  10. 10

    Zuelzer, W. W., Neel, J. V., and Robinson, A. R., “Progress in Hematology”, 1 (Grune and Stratton, New York, 1956).

    Google Scholar 

  11. 11

    Itano, H. A., “Ann. Rev. Biochem.”, 25, 331 (1956).

    Article  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

HUNT, J., INGRAM, V. Allelomorphism and the Chemical Differences of the Human Hæmoglobins A, S and C . Nature 181, 1062–1063 (1958). https://doi.org/10.1038/1811062a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing