Allelomorphism and the Chemical Differences of the Human Hæmoglobins A, S and C


IN previous communications on this subject, one of us1,2 reported that normal human hæmoglobin (A) and sickle-cell hæmoglobin (S) differ in only one out of nearly 300 amino-acids in the half-molecule, and that this is the only demonstrable difference in primary chemical structure. We now wish to report on a similar investigation into the structure of another abnormal human hæmoglobin—that of hæmoglobin C disease.

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HUNT, J., INGRAM, V. Allelomorphism and the Chemical Differences of the Human Hæmoglobins A, S and C . Nature 181, 1062–1063 (1958).

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