Letter | Published:

Transmembrane Potentials of Single Fibres of the Atrio-ventricular Node

Abstract

RECORDS of the electrical activity of the atrio-ventricular node obtained with extracellular electrodes1,2 have not provided a clear picture of the mechanism of normal atrio-ventricular delay or the changes responsible for partial and complete atrio-ventricular dissociation. In the experiments to be described the trans-membrane potentials of single fibres of the atrio-ventricular node and bundle of His have been recorded by means of intracellular micro-electrodes in order to obtain an answer to these questions. The atrio-ventricular node and His bundle have been studied either in the intact perfused rabbit heart or in isolated preparations of the right atrium and interatrial septum of the same heart. A modified Tyrode solution maintained at 33° C. was employed in both types of experiments. In most instances two intracellular micro-electrodes were employed simultaneously to demonstrate conduction delay and site of origin of activity. Similar results were obtained from both intact and isolated preparations.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Scher, A. M., Science, 121, 398 (1955).

  2. 2

    van der Kooi, M. W., Durrer, D., van Dam, R. th., and van der Tweel, L. H., Amer. Heart J., 51, 684 (1956).

  3. 3

    Hoffman, B. F., and Suckling, E. E., Amer. J. Physiol., 173, 212 (1953).

  4. 4

    West, T. C., J. Pharm. Exp. Therap., 115, 283 (1955).

  5. 5

    Draper, M. W., and Weidmann, S., J. Physiol., 115, 74 (1951).

  6. 6

    Katz, L. N., “Clinical Electrocardiography” (1956).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.