Letter | Published:

Antibody Formation by Isolated Cells of Hen Spleen after mixing with Antigen in vitro and Transfer to Chicks

Abstract

RECENTLY, Šterzl1 used newborn animals as recipients for the transfer of tissues producing antibodies as infant animals cannot produce antibodies after administration of antigens during the early postnatal period2. This experimental model has been used successfully by Mitchison3, who evoked antibody production in chicks after transfer of spleen tissue from strongly immunized hens. Dixon and Weigle4, however, were unable to demonstrate the usefulness of infant animals for the demonstration of antibody formation after transfer of tissues from animals immunized 24 hr. previously. In further work, when cells mixed with antigen in vitro were transferred, results were again negative5. In the work reported here, the possibility of using infant animals soon after birth as recipients was tested.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Šterzl, J., Immunological Conference of Czechoslovak Academy of Science (Nov. 29–Dec. 1, 1954); Fol. Biol., 1, 193 (1955).

  2. 2

    Šterzl, J., and Trnka, Z., Nature, 179, 918 (1957).

  3. 3

    Mitchison, N. A., Fol. Biol., 3, 72 (1957).

  4. 4

    Dixon, J. F., and Weigle, O. W., J. Exp. Med., 105, 75 (1957).

  5. 5

    Dixon, J. F., and Weigle, O. W., Fed. Proc., 16, 411 (1957).

  6. 6

    Sterzl, J., Fol. Biol., 3, 1 (1957).

  7. 7

    Simonsen, M., Acta Path. Mikrobiol. Scand., 40, 480 (1957).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.