Letter | Published:

Inhibiting Effect of Chlorpromazine on the Experimental Production of Liver Cancer


RECENTLY, Griffin, Rinfret and Corsigilia1 reported that development of hepatic tumours in rats fed on a diet containing 0.06 per cent 3′-methyl-4-dimethyl-aminoazobenzene may be effectively inhibited by hypophysectomy. Chlorpromazine is a phenothiazine derivative, which is used medicinally as a potent depressant for the interbrain. Aron, Guelfi and Voisin2 reported an atonic effect of this drug on the sensibility of the pituitary gland induced by stress.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Griffin, A. C., Rinfret, A. P., and Corsigilia, V. P., Cancer Research, 13, 77 (1953).

  2. 2

    Aron, E., Guelfi, J., and Voisin, A., C.R. Soc. Biol., 149, 891 (1955).

  3. 3

    Peters, K., Gärtner, H., and Krais, W., Strahlentherapie, 97/4, 579 (1955).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.