Letter | Published:

Inhibiting Effect of Chlorpromazine on the Experimental Production of Liver Cancer

Abstract

RECENTLY, Griffin, Rinfret and Corsigilia1 reported that development of hepatic tumours in rats fed on a diet containing 0.06 per cent 3′-methyl-4-dimethyl-aminoazobenzene may be effectively inhibited by hypophysectomy. Chlorpromazine is a phenothiazine derivative, which is used medicinally as a potent depressant for the interbrain. Aron, Guelfi and Voisin2 reported an atonic effect of this drug on the sensibility of the pituitary gland induced by stress.

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References

  1. 1

    Griffin, A. C., Rinfret, A. P., and Corsigilia, V. P., Cancer Research, 13, 77 (1953).

  2. 2

    Aron, E., Guelfi, J., and Voisin, A., C.R. Soc. Biol., 149, 891 (1955).

  3. 3

    Peters, K., Gärtner, H., and Krais, W., Strahlentherapie, 97/4, 579 (1955).

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