Letter | Published:

Activity of Glucose-I-phosphate on Liver Steatosis

Abstract

FOUR groups of rats were employed in studying the influence of glucose-1-phosphate on liver steatosis, induced by a high-fat, low-protein diet in rats: one, which served as control, was on a normal diet, and the remaining groups were placed on the steatogenous diet of Handler1 for 30 days. Of the latter groups one did not receive any treatment, one was treated with 3 gm./kgm. of glucose per os daily and the last one was treated with 3 gm./kgm. of glucose-1-phosphate daily. Treatment with glucose or glucose-1-phosphate was started 15 days after the administration of the steatogenous diet. The effect of treatment was studied by determining the liver content of total lipids, glycogen and easily hydrolysable phosphorus.

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References

  1. 1

    Handler, P., J. Biol. Chem., 173, 295 (1948).

  2. 2

    van der Vies, Biochem. J., 57, 410 (1954).

  3. 3

    Fenn, W. O., J. Biol. Chem., 128, 297 (1939).

  4. 4

    Le Page, G. A., “Manometric Techniques and Tissue Metabolism”, 185 (Burgess Pub. Co., Minneapolis, 1951).

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