Letter | Published:

The Anionic Polyelectrolyte, Polyethylene Sulphonate, as a New Anti-neoplastic Agent

Abstract

HEPARIN and related sulphomucopolysaccharides have been recognized as mitotic inhibitors for many years. Although heparin has been shown to inhibit cell division in many biological systems, including animal tumours1,2, its anticoagulant activity diminishes the likelihood of its producing anti-neoplastic activity in man at safe dose-levels.

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References

  1. 1

    Fischer, A., Arch. Path. Anat., 279, 94 (1931). Goerner, A., J. Lab. and Clin. Med., 16, 369 (1931). Zakrzewski, Z., Bull. Internat. Acad. Polonaise Sci. et Lett., Cl. de Med., 239 (1932). Heilbrunn, L. V., and Wilson, W. L., Proc. Soc. Exp. Biol. and Med., 70, 179 (1949). Balaza, A., and Holmgren, H. J., ibid., 72, 142 (1949).

  2. 2

    Runnstrom, J., and Krizat, G., Exp. Cell. Res., 1, 497 (1950).

  3. 3

    Hirschboeck, J. S., Madison, F. W., and Pisciotta, A. V., Amer. J. Med. Sci., 227, 279 (1954).

  4. 4

    Myers, K., Physiol. Rev., 27, 344 (1947).

  5. 5

    Fischer, A., Enzymologia, I, 3, 180 (1937).

  6. 6

    Roth, J. S., Arch. Biochem. Biophys., 44, 265 (1953).

  7. 7

    Fischer, A., and Sehmitz, A., Biochem. Z., 259, 61 (1933). McIntyre, A. P., and Braverman, I., Fed. Proc., 6, 158 (1947).

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