Letter | Published:

Effect of Hypoglycin A on the Alpha Cells of the Pancreas

Nature volume 180, pages 855856 (26 October 1957) | Download Citation



HYPOGLYCIN-A, which is isolated from the fruit of Blighia sapida, causes severe hypoglycæmia and depletion of liver glycogen1,2. Leppla and Holt3 examined the hypothesis that glucagon depletion following pancreatic alpha-cell damage might be the cause of these metabolic changes. However, as they could not find any microscopical changes in the alpha cells after hypoglycin A administration, they were unable to support this hypothesis.

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  1. 1.

    , , and , Nature, 173, 356 (1954).

  2. 2.

    , J. App. Physiol., 7, 140 (1954).

  3. 3.

    , and , Arch. Exp. Path. and Pharm., 228, 166 (1956).

  4. 4.

    , Amer. J. Path., 15, 497 (1939).

  5. 5.

    , Amer. J. Clin. Path., 20, 665 (1950).

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Author information


  1. Division of Pharmacology, Department of Physiology, University College of the West Indies, Jamaica.

    • P. C. FENG


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