Letter | Published:

The Hyaluronidase of the Leech: an Endoglucuronidase

Nature volume 180, pages 810811 (19 October 1957) | Download Citation

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Abstract

Two types of hyaluronidases have been described: one, found in testicular extracts and in snake venom, randomly cleaves the hexosaminidic bonds and yields a consecutive series from disaccharide through higher homologues of disaccharide units1; the other, found in micro-organisms, yields a Δ4–5 (glucuronido) unsaturated disaccharide2. In this communication, a third type of hyaluronidase is described, found thus far only in extracts of the leech (Hirudo medicinalis), which hydrolyses the endoglucuronidic linkages of hyaluronic acid.

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References

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Author information

Author notes

    • ALFRED LINKER

    Established investigator of the American Heart Association.

Affiliations

  1. Department of Medicine, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York.

    • ALFRED LINKER
    • , PHILIP HOFFMAN
    •  & KARL MEYER

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DOI

https://doi.org/10.1038/180810b0

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