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Xanthine Oxidase Activity during Mammary Carcinogenesis in Mice


SOME hypothetical and empirical considerations that form the basis of our interest in xanthine oxidase have been stated in the first of a series of publications1. The investigations of the chemical properties of xanthine oxidase1–3 have been extended to include the biological behaviour of this enzyme in normal and abnormal growth. The present communication deals with the xanthine oxidase activity in mammæ of mice of the C strain, with and without the milk factor, and in spontaneous mammary tumours. The studies of the enzyme activity in mammæ during pregnancy and lactation will be reported elsewhere.

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LEWIN, I., LEWIN, R. & BRAY, R. Xanthine Oxidase Activity during Mammary Carcinogenesis in Mice. Nature 180, 763–764 (1957).

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