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Attempt to transplant the Œdema Fluid of Experimental Inflammatory Œdema in Rats


According to the literature, the materials suspected of being either the cause of, or an important participant in, the different types of acute experimental inflammatory œdema in animals include histamine, hydroxytryptamine, some peptides (for example, leukotaxine, etc., of Menkin1), spreading factors (for example, Duran-Reynals2, McGovern3), the plasma protein permeability factor of Miles and Wilhelm4, and also certain nucleic acid derivatives (Spector and Willoughby5). The presence of at least the first two important members of these substances in œdema induced by testicular extract of the rat's hind-paw was demonstrated by Rowley and Benditt6 as well as in our laboratory. The histamine activity, for example, ranges from 2 to 10 µgm. in 1 ml. of œdema fluid.

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KELEMEN, E. Attempt to transplant the Œdema Fluid of Experimental Inflammatory Œdema in Rats. Nature 180, 710–711 (1957).

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