Attempt to transplant the Œdema Fluid of Experimental Inflammatory Œdema in Rats

Abstract

According to the literature, the materials suspected of being either the cause of, or an important participant in, the different types of acute experimental inflammatory œdema in animals include histamine, hydroxytryptamine, some peptides (for example, leukotaxine, etc., of Menkin¹), spreading factors (for example, Duran-Reynals², McGovern³), the plasma protein permeability factor of Miles and Wilhelm⁴, and also certain nucleic acid derivatives (Spector and Willoughby⁵). The presence of at least the first two important members of these substances in œdema induced by testicular extract of the rat's hind-paw was demonstrated by Rowley and Benditt⁶ as well as in our laboratory. The histamine activity, for example, ranges from 2 to 10 µgm. in 1 ml. of œdema fluid.