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Sodium Ions and Tissue Metabolism: Some Metabolic Peculiarities of Brain Tissue

Nature volume 180, pages 707708 (05 October 1957) | Download Citation

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Abstract

ACCORDING to Hodgkin and Katz1, in the complete absence of sodium ions from the surrounding medium, the action potential of the giant axon of the squid is diminished, whereas its resting potential is not changed at all. This observation of the effect of sodium ions on the electrical activity of nerve fibre is one of the bases of the sodium theory of nerve activity of the Cambridge school. So the metabolic effect of sodium-free medium on brain slices has been studied2, with special emphasis on its relation to the functioning of nerve cells in general, because the metabolic activity of nerve fibres is difficult to measure.

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References

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    , and , J. Physiol., 108, 37 (1949).

  2. 2.

    , and , J. Physiol., 117, 471 (1952). , and , Nature, 175, 725 (1955).

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    , and , Arch. Biochem. Biophys., [68, 196 (1957)].

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  1. Department of Physiology, School of Medicine, Keio University, Tokyo. April 2.

    • GENKICHIRO TAKAGAKI
    •  & YASUZO TSUKADA

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DOI

https://doi.org/10.1038/180707a0

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