Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Gene Mutations in Human Hæmoglobin: the Chemical Difference Between Normal and Sickle Cell Hæmoglobin

Nature volume 180, pages 326–328 (1957)Cite this article

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ingram, V. M., Nature, 178, 792 (1956).

    Article  ADS  CAS  Google Scholar 

  2. Michl, H., Monatsh. Chem., 82, 489 (1951).

    Article  CAS  Google Scholar 

  3. Sanger, F., and Tuppy, H., Biochem. J., 49, 463, 481 (1951). Sanger, F., and Thompson, E. O. P., Biochem. J., 53, 353, 356 (1953).

    Article  CAS  Google Scholar 

  4. Fraenkel-Conrat, H., Harris, J. I., and Levy, A. L., “Methods of Biochemical Analysis” 2, 359 (1955).

    Google Scholar 

  5. Edman, P., Acta Chem. Scand., 4, 277, 283 (1950).

    Article  CAS  Google Scholar 

  6. Perutz, M. F., Liquori, A. M., and Eirich, F., Nature, 167, 929 (1951).

    Article  CAS  Google Scholar 

  7. Schroeder, W. A., Rhinesmith, H. S., and Pauling, L. (in the press).

  8. Havinga E., and Itano, H. A., Proc. U.S. Nat. Acad. Sci., 39, 65 (1953).

    Article  ADS  CAS  Google Scholar 

  9. Pauling, L., Itano, H. A., Singer, S. J., and Wells, I. C., Science, 110, 543 (1949).

    Article  ADS  CAS  Google Scholar 

  10. Scheinberg, I. H., Harris, R. S., and Spitzer, J. L., Proc. U.S. Nat. Acad. Sci., 40, 777 (1954).

    Article  ADS  CAS  Google Scholar 

  11. Harris, J. I., Sanger, F., and Naughton, M. A., Arch. Biochem. Biophys., 65, 427 (1956).

    Article  CAS  Google Scholar 

  12. Neel, J. V., Science, 110, 64 (1949).

    Article  ADS  CAS  Google Scholar 

  13. Haldane, J. B. S., “Biochemistry of Genetics” (Allen and Unwin, London, 1954).

    Google Scholar 

  14. Benzer, S., in “The Chemical Basis of Heredity”, edit. by McElroy, W. D., and Glass, B., 70 (Johns Hopkins Press, Baltimore, 1957).

    Google Scholar 

  15. Streisinger, G., and Franklin, N. C., Cold Spring Harbor Symp. Quant. Biol., 21, 103 (1956).

    Article  CAS  Google Scholar 

  16. Pritchard, R. H., Heredity, 9, 343 (1955).

    Article  Google Scholar 

  17. Giles, N. H., Partridge, C. W. H., and Nelson, N. J., Proc. U.S. Nat. Acad. Sci., 43, 305 (1957).

    Article  ADS  CAS  Google Scholar 

  18. Itano, H. A., Ann. Rev. Biochem., 25, 331 (1956).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Council Unit for the Study of the Molecular Structure of Biological Systems, Cavendish Laboratory, University of Cambridge,

    V. M. INGRAM

Authors
  1. V. M. INGRAM
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

INGRAM, V. Gene Mutations in Human Hæmoglobin: the Chemical Difference Between Normal and Sickle Cell Hæmoglobin. Nature 180, 326–328 (1957). https://doi.org/10.1038/180326a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/180326a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing