Letter | Published:

Control of Humoral Factors of the Zona Glomerulosa of the Adrenal Cortex

Naturevolume 180pages14811482 (1957) | Download Citation



SELYE has reported1 that intraperitoneal injection of hypertonic saline resulted in characteristic changes in the zona glomerulosa of rat's adrenal gland. Broadening of the zona, blurring of cell outlines, foamy cytoplasm and swollen nuclei were seen in histological specimens. The fact that the zona glomerulosa can be stimulated by the sudden flooding of the organism with sodium chloride is rather striking in view of the statement that low sodium diet causes hypertrophy of this zone2–4. The effect is characteristic of sodium chloride, since other hypertonic solutions do not have the same action1. Kovács et al. have shown that the effect can be prevented by pretreatment with chloropromazine or by hypophysectomy5,6.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Selye, H., Acta Neuroveg., 6, 212 (1953).

  2. 2

    Deane, H. W., Shaw, J. H., and Greep, R. O., Endocrinol., 43, 133 (1948).

  3. 3

    Peschel, E., and Race, G. J., Amer. J. Med., 17, 335 (1954).

  4. 4

    Goldman, M. L., Ronzoni, E., and Schroeder, H. A., Endocrinol., 58, 57 (1956).

  5. 5

    Kovács, K., Horváth, É., Kovács, B. M., Kovács, G. S., and Petri, G., Arch. Intern. Pharmacodyn., 108, 170 (1956).

  6. 6

    Kovács, K., Kovács, B. M., Kovács, G. S., and Petri, G., Naturwiss., 44, 241 (1957).

  7. 7

    Fischer, J., and Inke, G., Acta Morphol., 7, 141 (1956).

  8. 8

    Giroud, C. J., Stachenko, S., and Venning, E. H., Proc. Soc. Exp. Biol. and Med., 92, 154 (1956).

  9. 9

    Hartroft, P. M., and Eisenstein, A. B., Endocrinol., 60, 641 (1957).

Download references

Author information


  1. Institute of Pathophysiology, Medical University, Szeged

    • A. NAGY
    • , A. OLAH
    •  & S. KARADY


  1. Search for A. NAGY in:

  2. Search for A. OLAH in:

  3. Search for S. KARADY in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.