THE importance of progesterone in adrenal function has been emphasized by a number of investigators. Beall and Reichstein1 isolated a small amount from adrenal extracts, and more recently Hechter and others2, using the perfused cow adrenal gland, showed that progesterone is an important intermediary metabolite for the synthesis of the adrenal corticoids. While the work reported here was in progress, Klopper et al. 3 demonstrated the presence of pregnanediol in the urine of ovariectomized women, but not in that of ovariectomized, adrenalectomized women. These, and other workers4, have inferred that the pregnanediol in these cases is of adrenal origin. The following results support this conclusion inasmuch as they show that the adrenal gland can secrete progesterone.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Beall, D., and Reichstein, T., Nature, 142, 479 (1938).
Hechter, O., Zaffaroni, A., Jacobsen, R. P., Levy, H., Jeanloz, R. M., Schenker, V., and Pincus, G., Recent Progr. Hormone Res., 6, 215 (1951).
Klopper, A., Strong, J. A., and Cook, L. R., J. Endocrin., 15, 180 (1957).
Bergstrand, C. G., and Gemzell, C. A., J. Clin. Endocrin., 17, 870 (1957).
Short, R. V., Ciba Foundation Colloquia on Endocrinology, 11 (in the press).
Rights and permissions
About this article
Cite this article
BALFOUR, W., COMLINE, R. & SHORT, R. Secretion of Progesterone by the Adrenal Gland. Nature 180, 1480–1481 (1957). https://doi.org/10.1038/1801480a0
This article is cited by
Interference of Mycotoxins with Prenatal Development of the Mouse
Acta Veterinaria Scandinavica (1981)
Plasma Progesterone Concentration after Removal of the Corpus Luteum in the Cow
Biosynthèse des hormones stéroïdes
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.