IN order to render staphylococcal toxic supernatants safe for use as active immunizing agents, it is customary to incubate them with formalin, in concentrations of 0.3–0.8 per cent at temperatures between 37° and 40° C. for periods of up to two weeks1,2.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Dolman, C. E., J. Amer. Med. Assoc., 100, 1007 (1933).
Rouyer, M., Pillett, J., Orta, B., and Nicol, M. J., Ann. Inst. Pasteur, 92, 276 (1957).
Boake, W. C., J. Immunol., 76, 89 (1956).
Burnet, F. M., J. Path. and Bact., 34, 471 (1931).
Rights and permissions
About this article
Cite this article
FISHER, S. Loss of Immunizing Power of Staphylococcal Toxin during Routine Toxoiding with Formalin. Nature 180, 1479–1480 (1957). https://doi.org/10.1038/1801479b0
This article is cited by
Influence of human milk on the development of antistaphylococcal immunity
Antonie van Leeuwenhoek (1970)
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.