Abstract
IN order to render staphylococcal toxic supernatants safe for use as active immunizing agents, it is customary to incubate them with formalin, in concentrations of 0.3–0.8 per cent at temperatures between 37° and 40° C. for periods of up to two weeks1,2.
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References
Dolman, C. E., J. Amer. Med. Assoc., 100, 1007 (1933).
Rouyer, M., Pillett, J., Orta, B., and Nicol, M. J., Ann. Inst. Pasteur, 92, 276 (1957).
Boake, W. C., J. Immunol., 76, 89 (1956).
Burnet, F. M., J. Path. and Bact., 34, 471 (1931).
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FISHER, S. Loss of Immunizing Power of Staphylococcal Toxin during Routine Toxoiding with Formalin. Nature 180, 1479–1480 (1957). https://doi.org/10.1038/1801479b0
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DOI: https://doi.org/10.1038/1801479b0
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