Letter | Published:

Radiation Lethality and Local Tissue Damage in Histamine-depleted Rats

Naturevolume 180page1467 (1957) | Download Citation



THE liberation of histamine from cells damaged by ionizing radiations is considered to play an important part in certain radiation changes, particularly in skin erythema and in certain aspects of the acute radiation syndrome1. While some elevation of plasma histamine is said to occur after total-body irradiation2, estimations of tissue histamine following irradiation have been reported unchanged3 or lowered4. The administration of histamine at the time of irradiation, to animals subjected to lethal doses of total-body irradiation, has been found to afford a weak but variable protective effect5.

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    Ellinger, F., Schweiz. Med. Wochschr., 81, 61 (1951).

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    Painter, E. E., Prosser, C. L., and Moore, M. C., U.S. At. Energy Com. Report M.D.D.C., 761 (1947). Weber, R. P., and Steggerda, F. R., Proc. Soc. Exp. Biol. Med., 70, 261 (1949).

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    Ungar, G., and Daamgard, E., Proc. Soc. Exp. Biol. Med., 87, 383 (1954).

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    Eisen, V. D., Ellis, R. E., and Wilson, C. W. M., J. Physiol., 133, 506 (1956).

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    Bacq, Z. M., and Herve, A., quoted by Bacq, Z. M., and Alexander, P., in “Fundamentals of Radiobiology” (Butterworths Scientific Publications, London, 1955).

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    MacIntosh, F. C., and Paton, W. D. M., J. Physiol., 109, 190 (1949).

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    Feldberg, W., and Talesnik, J., J. Physiol., 120, 550 (1953).

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    Riley, J. F., and West, B. G., J. Path. Bact., 69, 269 (1955).

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  1. Radiobiological Research Unit, Cancer Institute Board, Victoria, Australia

    • H. A. S. VAN DEN BRENK


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